Frederick, MD United States
SAIC-Frederick, Inc., is a wholly owned subsidiary of Science Applications International Corporation (SAIC). As prime contractor for the National Cancer Institute’s research and development center in Frederick, MD, this national laboratory is dedicated to rapidly translating basic research into new technologies for diagnosing, treating, and preventing cancer and AIDS. SAIC-Frederick maintains a full suite of advanced technologies in areas such as nanotechnology, genomics and imaging; operates the federal government’s only drug and vaccine manufacturing facilities; operates the high-performance Advanced Biomedical Computing Center; and supports more than 300 clinical trials for patients in the US and around the world.
The NCI’s Developmental Therapeutics Program’s (DTP) mission is the discovery, development and characterization of new anticancer drugs and their molecular targets The position will provide senior scientific leadership for SAIC-Frederick’s laboratory support of the Toxicology & Pharmacology Branch, DTP, Division of Cancer Treatment & Diagnosis. The Investigative and In Vitro Toxicology Sections investigate toxicologic mechanisms and evaluate molecular toxicology, cellular toxicology and early ADME properties of experimental and investigational anticancer agents, using best available technologies, in vitro systems or newly developed ones as needed.
Responsibilities of this position include directing and managing the laboratory program to maximize SAIC-Frederick’s contributions to the success of the Branch’s mission within DTP and within the NCI’s NExT Program during interactions with project teams and other groups; serving as the daily point of scientific/technical contact for government officials of the Branch and the larger DTP organization; programming new laboratory support of the Branch’s molecular toxicology effort; leading the scientific and technical staff of the laboratory, including recruitment of open positions, to assure successful completion of projects and technical tasks; and managing lab operations and resources within SAIC-Frederick’s corporate organization, including assisting the Director of the Laboratory of Human Toxicology and Pharmacology in program management and coordination.
REQUIRED SKILLS: Possession of a Doctoral degree (e.g., D.V.M., Ph.D., D.Sc., M.D.) from an accredited college or university appropriate to toxicology, drug safety and/or pharmacology. Foreign educated candidates who have completed part or all of their education outside of the United States must have their foreign education evaluated by an SAIC-approved accrediting organization to assure that it has met the equivalency of the qualifications of degree work in the United States. Must have at least eight years of postgraduate experience in the investigation and assessment of molecular targeted drug effects and modulation of protein and/or gene function, using advanced biochemical, biophysical, in silico, molecular biology and other analytical techniques. Must have at least five years of experience in molecular toxicology analysis and data interpretation, and evidence of successful laboratory programming and implementation of these activities that have made a positive impact upon a developmental therapeutics program. Must have at least three years of experience managing a laboratory and supervising both scientific and technical staff. Must possess the ability to convert toxicological questions into laboratory-based, experimental investigations of molecular mechanisms, and provide evidence of peer recognition of this ability (first authored publications in peer reviewed journals, group leadership experience in industry, platform presentations at national meetings, etc). This position is subject to obtaining a Public Trust Clearance.
DESIRED SKILLS: Ability to develop and implement new research plans for complex projects involving molecular biology, targeted therapeutics and new and/or innovative assays of molecular drug effects (both on- and off-target), and foresee the technical achievements that will be required to provide definitive answers to key toxicology questions. Ability to translate laboratory-based results into the toxicology setting, including integration with animal modeling and clinical toxicology findings. Ability to judge emergent technologies in the private sector and provide rationale for decisions about outsourcing molecular toxicology tasks versus developing in-house capability. Ability to clearly present and articulate toxicological findings and principles to project teams and more general audiences using verbal and written communication. Demonstrated leadership ability and interest in developmental therapeutics for cancer. Nationally recognized leadership in molecular toxicology.
Job code: 178586