SAIC-Frederick, Inc., is a wholly owned subsidiary of Science Applications International Corporation (SAIC). As prime contractor for the National Cancer Institute’s research and development center in Frederick, MD, this national laboratory is dedicated to rapidly translating basic research into new technologies for diagnosing, treating, and preventing cancer and AIDS. SAIC-Frederick maintains a full suite of advanced technologies in areas such as nanotechnology, genomics and imaging; operates the federal government’s only drug and vaccine manufacturing facilities; operates the high-performance Advanced Biomedical Computing Center; and supports more than 300 clinical trials for patients in the US and around the world.
THIS IS AN AMERICAN RECOVERY AND REINVESTMENT ACT (ARRA) FUNDED POSITION. The Pharmacodynamics Section of the Laboratory of Human Toxicology and Pharmacology, SAIC-Frederick, Inc., NCI-Frederick is seeking a Post-Doctoral Fellow to assist in the development and validation of quantitative multiplex assays to be used in assessing patient response to new anti-cancer agents. Technology platforms will be centered on multiplexed immunoassays for assays of drug molecular targets in tumors and other solid tissues. Responsibilities will include assessment of assay specific reagents and calibrators, testing prototype assays developed by commercial vendors specifically for NCI, transfer of validated assays and platforms into NCI, and Fitness for purpose testing on human tissues, including both xenograft models and patient specimens. The successful candidate will be contemplating a professional career in translational research or clinical chemistry. A desire to advance the discipline of pharmacodynamics and improve cancer patient treatment will be a strong commitment of fellows in this program.
Possession of a Doctoral degree in a quantitative science from an accredited college or university, in a field related to biomedical research. Foreign educated candidates who have completed part or all of their education outside of the United States must have their foreign education evaluated by an SAIC-approved accrediting organization to assure that it has met the equivalency of the qualifications of degree work in the United States. In addition to the education requirement, relevant experience in tissue handling, quantitative immunoassay and either cancer biology or pharmacology are required. Familiarity with statistical software designed for biological testing is required. Must have excellent written and oral communication skills. Must have the ability to read, understand and abstract technical reports and the relevant research literature and internet documents issued by relevant regulatory agencies. This position is subject to obtaining a Public Trust Clearance.
Experience in clinical specimen preparation and testing (molecular biology, chemistry, immunoassay) is highly desired. Previous experience with laboratory information management systems, operating under and generating SOPs preferred. Scientific (laboratory or manufacturing) or Applications Development experience in at least one of the following fields: clinical immunoassay, immunofluorescence or clinical chemistry. General knowledge of GxP requirements and guidelines will be helpful.