RNA preparation in lab seems to be quite difficult because of RNase, an enzyme which cuts RNA instantaneously as this enzyme is everywhere and thus making the RNA a difficult task for researchers. Now researchers claim that they have developed a technique so that they can bypass the enzyme and thus can prepare a stable RNA molecule that has 3D configuration.
RNA is one of the latest tools in Nanotechnology as it can find many applications once it is manipulated, however so far it was susceptible to breakage in the presence of enzyme, however this new study can give the researchers a boost to use RNA in nanotechnology applications. Researchers Peixuan Guo and his team at University of Cincinnati (UC) have recently published their findings in the journal ACS Nano.
RNA consists of ribose ring alternately with phosphate group and researchers selected the ribose ring and changed one section of this ribose ring and thus by altering the structure of the molecule, the RNase could not bind with it and thus breakdown it. A previous study has claimed that the RNA if changed can be stable in helix form; however no studies conducted in past claims the 3-D structure.
Researchers not only created the 3-D structure of the RNA but used it in DNA packing nanometer and found that it fold into 3-D structure appropriately and can carry out the functions after modifications properly. Therefore, RNA can not only be modified as a stable RNA but it can suitably be applied to nanotechnology applications.