The Nano eNabler System™ prints proteins and other biological and non-biological materials onto silicon chips and other surfaces with ultra-micro spot sizes ranging from 20 microns to 1 micron, and in the nanometer range to 250 nm. Ultramicro- or nanoarrays of up to 10-50 domains or more can readily be produced and can subsequently be used as ultraminiature test sites for biomolecular interactions.