Effect Of Lymphatic Targeting? Application Delivery System To Create A New World Of Nanotechnology

That in the treatment of lymphatic metastasis, people try to use liposomes or nanoparticles such as a carrier of anticancer drug delivery, the transfer of drug to reach the lymph nodes and slow release, thus prolonging the duration of action of drugs, improve treatment and reduce systemic adverse drug reactions.

In fact, in addition to cancer metastasis, the immune diseases, inflammation, lymphatic filariasis and other similar lesions in the lymphatic system for the disease, with direct delivery of drugs to the lymphatic system, a non-invasive means, so that drugs play a more direct and satisfactory efficacy, clinical treatment is the better choice. Nanoparticles in the diagnosis, monitoring and treatment of wide range of applications. In these areas, progress in recent years, nanotechnology will soon, and some have entered the application phase, and some have entered clinical phase, while more are in various stages of the pilot study.

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Drug-loaded nanoparticles as a huge surface area, good bioavailability and in vivo distribution characteristics of a lymph node has a promising weapon targeting.

Ways Posts: 5 kinds of drug delivery similar weight

According to different administration methods, nano-drug delivery system for lymphatic targeting mechanism has the following five.

Gastrointestinal drug delivery Recent years, nano-carriers for drugs, gastrointestinal absorption nonvolatile memories. Small intestine of humans and animals there are certain organizations and immune-related areas such as accounting for the intestinal mucosa about 1 / 4 of the Peyer’s assembly (PP). Study found, oral administration, the microparticles through the intestinal epithelial cells reach the spleen and lymph through the PP system organs, and the smaller size, the better the absorption.

Some nanoparticles, such as chitosan, in the swelling state can temporarily open or widen the tight junctions between epithelial cells of the channel, thus contributing to particle transport. Lipid carrier materials for the nano-delivery systems, such as nano-liposomes, solid lipid nanoparticles, oral fat-soluble macromolecular material when its role in bile acid mixed micelles formed by glycerol intestinal epithelial cells stearic acid pathway, to form chylomicron targeted in mesenteric lymph.

Interstitial administration When to Nanoparticles for subcutaneous, intramuscular, cancer and other interstitial week administration, the particles were also facing capillaries and lymphatic capillaries of the transfer and uptake, mainly depends on the means by which the drug particles nature, such as size, surface and so on. Since endothelial cells connected loosely, often much open space there, particles and macromolecules through the lymphatic endothelial cells and endothelial cells of the cellular space to drink and phagocytosis into lymphatic capillaries and subsequently reach the regional lymph nodes through lymphatic drainage. The size of particles and macromolecules in a few nanometer, most enter the capillaries, the tens of nano-particles can be absorbed by lymphatic capillaries, several hundred nanometers or larger particles will be a long time stuck in the interstitial space ri.

Mucosal drug delivery Nardelli-Haefliger, etc. with attenuated Salmonella expressing hepatitis B virus particles, for nasal mucosal immunity, found that compared with oral immunization can induce antibodies more effective immune induction, but with a strong dose-dependent . In fact, the mucosal immunity of drug delivery has given rise to attention. The common mucosal immune antigen are required to act on the drug that is related to the lymphatic system, specifically, the drug is the carrier of a certain form of antigen to reach through the mucosal surface and release, and targeting the regional lymph nodes in the mucosa, acting on the associated lymphoid tissue, eventually induce humoral and cellular immunity. Immunization lungs, inflammation, cancer and parasitic diseases are a class of therapeutic approaches to drug targeting to alveolar macrophages (AMs), and a significant proportion of alveolar macrophages are transported to the lymphatic system. Protein peptides to liposomes, microspheres and other carriers form of pulmonary mucosal drug delivery can be targeted to the lymph is the completion of this task means a class of effective.

Vascular administration

Although colloid systems, because of its size difficult to cross the capillary permeability barrier, thus not conducive to lymphatic vascular targeting drug delivery, this delivery method is still of concern. Institute of Pharmacology and Toxicology, Military Medical Academy, Yang left mouse or rabbit secondary to intravenous injection of India ink or nano-activated carbon, in the mesentery, abdominal aortic paraneoplastic retroperitoneal lymph node observed a large number of particles within. Accordingly, their analysis, intravenous administration, the reticuloendothelial system (RES) First of all, eat a lot of nano-particles, it contains a large number of macrophages in tissue such as liver, lung, spleen and lymph nodes will gather more nano-particles.